In this article, we summarize more than a decade of work on high-leverage practices being used in the context of science teacher preparation. We describe the challenges and insights that ultimately resulted in more robust practices, a diversified suite of tools to support these practices, expanded knowledge of our own teacher education pedagogies, and stronger bonds between our preparation program and its local network of K-12 schools. The special education community has now formulated an ambitious practice-based vision for professional preparation, and advocates will find our narratives to be a mix of cautionary tales and cause for optimism.