This study aims to integrate kinesthetic technology and collaborative learning into total physical response (TPR) and to investigate the effect of collaborative total physical response (CTPR) on English language acquisition by high school students. To accomplish this, we utilized Microsoft Kinects to develop Collaborative Kinesthetic English Learning (CKEL) system designed to accommodate students in pairs during collaborative English learning activities. Thus, we observed significantly improved learning outcomes in the experimental group relative to the control groups in both total score and vocabulary part of the post-test. However, tests carried out for learning different kinds of vocabulary based on CTPR were also analyzed, and the results showed no significant difference between verbs, nouns or adjectives. This experiment revealed that this system would possibly be helpful for English learning regardless of the kind of vocabulary targeted. Therefore, we concluded that CTPR is not only more helpful for English learning than the traditional individual TPR but also worth being employed and requires further exploration in facilitating English learning.