Background: School-based health centers (SBHCs) provide primary and preventive health services and have been debated as possible medical homes for the pediatric population. The effect of a SBHC as an expanded medical home has yet to be determined. Objective: The purpose of this paper was to review the research evaluating the use of SBHCs as a pediatric patient's expanded medical home. Methods: The databases PubMed and CINAHL were searched for research articles pertaining to the value of using a SBHC as a pediatric medical home. Results: SBHCs provide care that is accessible, coordinated, comprehensive, continuous, family-centered, compassionate, and mildly culturally effective for adolescents. Conclusions: Community health systems and primary care providers should partner with SBHCs to establish an expanded medical home and promote greater coordination and continuity of care for adolescents.