A growing number of studies have demonstrated that purpose in life is associated with positive outcomes among adolescents and young adults. The college years represent an important period of both personal and professional growth, including purpose in life. Supportive relationships may play a critical role in the identification and pursuit of purpose. Relationships with mentors, for example, have been linked with purpose among adolescents. The present study examined whether mentoring relationships were linked with purpose among college students (N = 194) from three institutions across the United States. Both aspects of quality (relational health) and quantity (i.e., number of mentors) were examined as predictors of purpose. Students who had at least one mentor reported higher levels of purpose compared to students with no mentors. Among students with at least one mentor, quality of mentoring was significantly associated with a greater commitment to purpose, while the number of mentors was not associated with commitment to purpose. Results are discussed in the context of practical applications regarding student success and purpose formation in higher education settings.