Interventions often require multiple decisions to improve outcomes for every student. Whether the decision to implement a practice, tailor an existing protocol, or change approaches, these decisions should be based on individual variables and outcomes via a sequence of treatment. To develop adaptive interventions that have sufficient evidence to support decisions, components, and sequences, they must be evaluated as they operate. The sequential multiple-assignment randomized trial is a design that experimentally assesses the efficacy of the decisions, components, and sequence of an adaptive intervention. The purpose of this article is to provide an overview of this novel methodology and describe how this design can provide meaningful information about components and sequence based on individual differences and response to maximize educational outcomes in special education.