For many reasons, physiological aspects of anatomy and physiology laboratories are often presented as simulations. While simulations effectively convey concepts, hands-on activities promote more active student engagement. Recycled soda bottles, supplemented with other inexpensive readily available supplies, can be used to create working models illustrating concepts such as filtration at the glomerulus with reabsorption from the renal tubules, heart valve regulation of flow direction, negative pressure of inhalation, and fluid conduction of sound waves in the inner ear. These activities demonstrate basic biological properties, and allow for more in-depth student exploration resulting in enhanced cognition. The activities are well received by students who find them to be informative and fun. In this article, readers are guided through the construction of a model nephron with detailed step-by-step instructions and assessment tools.