We used 3D printing to manufacture models that allow students to explore antibody-epitope interactions. One of the more difficult concepts for students in general microbiology and immunology courses is visualizing the interactions surrounding antibodies and the multiple epitopes found on antigens. We designed and printed antibodies that recognize different epitopes on the same viral antigen. Students can match different heavy chains and light chains creating 4 possible antigen-binding regions and then attempt to determine if and where on 3 possible viral antigens the antibody would bind. In this article we describe using 3D printing to create kits that can be used to demonstrate difficult concepts to students. The process used to develop these kits will be described as well as how the kits are used in large lecture (up to 150 students) flipped classes to augment student learning.