Objective: This study examines the relationship between adverse childhood experiences (ACEs) and academic barriers to college success. Participants: College students (n = 525) were surveyed about exposure to ACEs and academic barriers on a large university campus in the Southeast. Methods: Multivariate regression was used to model the academic barriers among college students for students with different levels of ACEs exposure controlling for depression, health and family barriers, and sociodemographic characteristics. Results: Students with ACEs reported more family difficulties and health problems compared with those without ACEs. Depressive symptomology, poorer health ratings, and other health and family issues significantly predicted higher counts of academic barriers. Conclusions: Students with ACEs face greater difficulty with relation to health and family barriers which in turn impacts academic barriers.