The EMES-16 is a very short multidimensional measure of domain-specific Self-Esteem designed for French-speaking adolescents. This study presents a psychometric evaluation of this measure among 2603 adolescents with a focus on its factor structure tested in CFA for alternative, theoretically grounded models. Results revealed the superiority of a domain-specific, and partly hierarchical structure, over unidimensional or fully hierarchical structures. This structure supports the derivation of five domain-specific scores (Emotional, Social, Physical, Academic and Creative Self-Esteem) as well as a superordinate composite index (Core Self-Evaluation) underlying the Emotional, Social and Physical Self-Esteem. Measurement invariance testing supported partial equivalence of the construct measured by the EMES-16 across gender and strict equivalence by age groups. Construct validity evaluation suggested strong evidence of EMES-16's scores convergent and divergent validity with measures of unidimensional Self-Esteem, Self-Concept Clarity, Big Five Personality and Social Desirability. Internal consistency was also satisfactory given the concision of the EMES-16 scales. In conclusion, we discuss the promise of the EMES-16 as a psychometrically solid measure for screening and developmental research purposes among French-speaking adolescents.