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ERIC Number: EJ1220868
Record Type: Journal
Publication Date: 2019-Jul
Pages: 11
Abstractor: As Provided
ISSN: ISSN-0162-3257
Widespread Disrupted White Matter Microstructure in Autism Spectrum Disorders
Fitzgerald, Jacqueline; Gallagher, Louise; McGrath, Jane
Journal of Autism and Developmental Disorders, v49 n7 p2664-2674 Jul 2019
Autism Spectrum Disorders (ASDs) are characterised by impaired social communication and restricted repetitive behaviours. Researchers posit that these core features may be underpinned by disrupted structural connectivity. A tract based spatial statistical analysis of diffusion MRI data was performed to investigate white matter organisation (an indication of structural connectivity) in a well-defined cohort of 45 ASD and 45 age and IQ matched control participants. Aberrant structural connectivity characterised by reduced fractional anisotropy was observed in several fiber pathways in ASD relative to controls. Disrupted white matter organisation was associated with social deficits and restricted repetitive behaviours in ASD. Abnormal structural connectivity is apparent in ASD and may be linked to the core behavioural features of the disorder.
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Publication Type: Journal Articles; Reports - Research
Education Level: N/A
Audience: N/A
Language: English
Sponsor: N/A
Authoring Institution: N/A
Grant or Contract Numbers: N/A