ICT is a key role player in higher education institutions for pedagogical practices. This paper is aimed at exploring the role of ICT in the Ethiopian higher education system. In the Ethiopian Higher Education system there are movements to integrate ICT into teaching and learning practices. However, the implementation is inadequate. Factors like limited infrastructure, user's attitude towards ICT, management support, skilled human resources and policy issues supporting ICT integration are affecting the implementation of ICT in Ethiopian higher education. To explore the role of ICT in the higher education system of Ethiopia, the researcher reviewed the literature and interviewed professionals from the Ministry of Education and the Ministry of Science and Technology. The findings of the study indicated the lack of an ICT policy for pedagogical practices as the main challenge to the integration of ICT in teaching and learning. Further, lack of support from top management, implementation problems, lack of training for instructors and experts, the structure of ICT service under the administrative unit, and student's skill to use ICT for their learning are considered as the critical problems impacting the integration of ICT for pedagogical practices.