Most universities in Uganda encourage memorization as the predominant method of learning. This has been partly linked to limited practical pedagogical skills among educators, to effectively engage students to develop Higher Order Thinking Skills (HOTS). Consequently, students are not well prepared for the world after university. WhatsApp Enabled Learning (WAEL) has been found to support approaches to learning that promote development of HOTS, like inquiry, creativity, critical reflection and dialogue. Although many universities in Uganda have been using LMSs, there is little evidence that use of an LMS has enhanced development of HOTS. While the Ugandan society is catching on fast with use of WhatsApp due to increased access to mobile technology devices and Internet connectivity, use of WhatsApp in education is still limited. Additionally, there is limited research on the benefits of WAEL to development of HOTS in African countries. This paper examines how WAEL can facilitate development of HOTS through a general literature analysis and using the Activity Theory (AT) framework. The results show that WhatsApp has a great potential to support development of HOTS due to its affordances such as ubiquity, and AT provides a systematic and practical way to demonstrate this potential and how it can be applied.