Temperament and personality traits constitute inherent and learned personal characteristics that are crucial for creative behaviors among high ability students. This study investigated the relationships of temperament dimensions and the Big Five personality traits to creativity among 406 honors college students. First, the associations of creativity with temperament and personality were investigated separately. Second, it was sought to document if the selected measures of personality and temperament are distinguishable despite their interdependence. Finally, a mediational role for personality traits in channeling the effect of temperament on creativity was hypothesized. In the mediation model, all four temperament dimensions (orienting sensitivity, effortful control, extraversion/surgency, negative affect) had direct or indirect relationships with creativity. Two personality traits (openness, neuroticism) were found to be significant mediators in these relationships. The findings were discussed in terms of their relevance to the high-ability college students and to the temperament, personality, and creativity literature in general.