Student of Color often reference racial microaggressions when asked to describe their post-secondary experience. The racial battle fatigue framework assists in understanding the cumulative, negative effect of racial microaggressions on psychological, behavioral, and physiological outcomes. This paper assesses the racial battle fatigue framework for African American and Mexican American college students and the impact of coping on racial stress. Results demonstrate that racial microaggressions negatively impact stress responses for African American and Mexican Americans differently, but coping may help alleviate the impact of racial battle fatigue. Universities can address racial microaggressions and negative health outcomes by educating campus constituents about racial microaggressions, addressing Whiteness, and providing education about adaptive coping strategies.