This study examined how presence of meaning in life, search for meaning in life, hope, gratitude, enculturation, and family influenced Hispanic/Latino college students' depression and subjective happiness. The first regression model showed that hope, presence of meaning in life, family, and search for meaning in life were related with depression. The second showed that gratitude and presence of meaning in life were related with subjective happiness. Findings and recommendations for counselors and higher education professionals are provided.