Students with specific learning disabilities (SLD) typically do not perform at the expected levels of academic achievement. Tangible mobile applications are learning devices that allow for physical engagement and multisensory interaction. They present as promising tools to facilitate learning for students with SLD. This study explored the use of a tangible mobile application for assisting three seventh-grade Turkish students with SLD to learn scientific principles regarding cell concepts. A multiple-probe design across participants was used to examine the effectiveness of a tangible mobile application. In addition, issues related to usability of the application were also explored. The overall results of the study showed that the tangible mobile application was effective, and the students with SLD were willing to use this application, enjoyed the process, and used the application and objects easily/correctly.