Since the beginning of the use of the e-learning concept in the 1990s, in the context of the information and knowledge society, there has been an explosion of different interpretations and approaches in Higher Education. This range of different interpretations and approaches can lead to a confusing and even contradictory situation given the many different perspectives that give rise to these attempts to explain the concept. Open and face-to-face Universities apply different e-learning models according to their goals, mission and national legislation. The aim of this paper is to present the model chosen by the European University Cyprus, a face-to-face university, which has recently started the implementation of autonomous distance learning master degree programs. The presentation and analysis of different case studies about the e-learning models can create the concept's roadmap in Higher Education and help policy makers to decide which model corresponds better to the characteristics, mission and needs of their institutions.