Clinical research during the pregnancy period is maximally beneficial for participants if it is positive, inclusive, and therapeutic. We describe our ongoing study of ethnically diverse, low-income pregnant women and fathers-to-be that leverages participants' benevolent childhood experiences (BCEs) and promotes insight to counteract mental health and relationship problems before babies are born. Although many participants report extensive childhood trauma, cumulative stress, and elevated depression and posttraumatic stress disorder (PTSD) symptoms, most also report high levels of BCEs, which show promising associations with well-being. Participant reflections at the end of the study illustrate that they feel their stories are valued, learn to connect past experiences to present functioning, gain insights about their romantic relationships, and enjoy the research experience.