Ferguson, like many at-risk suburbs, has largely been lost in discussions of the geography of opportunity. The authors conducted a descriptive epidemiological case study of Ferguson and its surrounding region with a focus on health and education indicators. Drawing from a variety of community data sources, they used geospatial methods to investigate the interdependence of place, education, and health across the metropolitan region. Results revealed the nature and distribution of class and racial disparities across the region. The legacy of the regional segregation regime indicates that substantive reform is required. Recommendations to improve education and health outcomes include eliminating political fragmentation with a unification strategy for the region and health insurance for families without coverage.