This study explored the organizational culture, organizational commitment and job satisfaction of the faculty members of the St. Paul University System (SPUS). This study employed a descriptive and correlational research design. The data gathered were analyzed and interpreted using frequency and percentage distribution to confirm statistical assumptions and to describe the participants' profile in terms of the identified variables. The weighted mean was used to interpret the responses obtained from the use of the Likert's scale. The regression analysis was used to determine the best predictors of job satisfaction and organizational commitment while Pearson and Chi-Square were used to determine the degree of relationship between the variables. The results of this study indicate that there is a significant positive relationship between job satisfaction and organizational culture. It was also found out that job satisfaction predicts organizational commitment. The results of this study will be a basis for the SPUS to strengthen the organizational commitment and explore various ways to raise the level of job satisfaction of the faculty members of the respondent-institutions.