This study explored the effects of processing texts in print or digitally on readers' comprehension, processing time, and calibration. Eighty-six undergraduates read print and digital versions of book excerpts about childhood ailments presented in counterbalanced order. Comprehension was tested at three levels (i.e., main idea, key points, and other relevant information). Direct comparisons between print and digital reading demonstrated a significant advantage for reading in print on students' recall of key points and other relevant information but not the main idea. When processing time was added as a mediator variable, it significantly affected the relation between medium and comprehension for all question levels. In terms of calibration, students read more quickly and judged their performance higher when engaged digitally, although their actual performance was much better when reading in print. Implications of these findings for subsequent research are considered.