Student-centered instruction is featured in reforms that aim to improve excellence and equity in mathematics education. Although research on stereotype threat suggests that student-centered instruction may have differential effects on racial minority students, the relationship between student-centered mathematics instruction and student engagement remains understudied. This study examined the relationship between student-centered mathematics instruction and adolescents' behavioral, cognitive, emotional, and social engagement in mathematics and whether the relationship differed by ethnicity. The authors used a multilevel path analysis with data from 3,883 sixth- to 12th-grade students (52.1% girls, 38.2% eligible for free/reduced lunch, 66.1% Caucasian, 23.8% African American, 7.2% multiracial, and 2.9% Asian American). The results showed that student-centered instruction was positively related to all dimensions of mathematics engagement. However, the positive association between student-centered mathematics instruction and student engagement was weaker for African American students. This study provides empirical evidence for the benefits of student-centered instruction while suggesting differential effects based on students' ethnicity.