The authors set out to determine the brain dominance characteristics of students enrolled in business statistics courses in a historically Black university in a major southeastern Texas city. Thereafter, the authors investigated the relationship between a student's brain hemispheric preference and academic performance in college courses, which emphasize problem solving. The results reported in this study reveal that left brain--and right brain--dominant students are at parity when it comes to performance in a problem-solving course. Moreover, both left brain-- and right brain--dominant learners perform better than whole-brain dominant learners in a problem-solving course.