The places where high school teachers teach have a relationship with what and how their students learn. Certain aspects of the physical environment have been examined for decades, such as those that affect basic physiological needs including but not limited to climate control, air quality, appropriate lighting, and cleanliness. In addition to these needs, it is important to examine learning spaces in light of the changing pedagogies that teachers are being encouraged to employ with this current generation of students. Pedagogies are continually being added to and adapted; however, improvements in the physical environment are not always considered components of these curriculum adjustments. Without the proper facilities, teachers are limited in the pedagogical techniques they can utilize. As teachers are being required to differentiate teaching strategies, they need to be provided with the appropriate resources, including the most effective physical environments and classroom layouts and the training to use those spaces effectively. Continued studies are necessary to elucidate evidence for those aspects of the physical learning environment that are most effective for aiding in 21st century learning.