On 26 and 27 September 2014, 43 students from the "Profesor Isidro Burgos" Rural Normal School in Ayotzinapa, Guerrero, Mexico, disappeared, and six people died. In this article, I analyse the event as the result of long-term historical processes, from the perspective of the social mobilisation that caused the students' disappearance on the one hand, and from the history of rural normal schools on the other. The starting point is to relocate political history within the history of education in order to understand the agency of political actors in the definition of educational processes, and the questioning of the reciprocal relations of school and state. The study is based on widely diverse sources: official documents from schools, statistics, news items from newspapers and social networks, and observations of the mobilisations of 2014. The disappearance of the 43 rural normal students is the result of a long process of abandonment in the countryside, of discrimination against young people of rural origin and Indians, all in the framework of a process of state dismantling which places teachers and normal students in positions of severe vulnerability.