Using a mixed-methods approach, the researchers explored the experiences of 108 academic librarians who served as interim library leaders at U.S. institutions of higher education between 2012 and 2017. Statistical analysis showed no associations between gender, type of institution, or degree-granting level with the duration of interim service or whether a respondent applied for or was hired as the permanent leader. The authors provide recommendations for future interim library leaders and the university executives who appoint them. Serving as an interim library leader can be a once-in-a lifetime opportunity well worth the experience.