This study investigated the impact of age, gender, language and acculturation choice on the sociocultural adjustment and well-being of Syrian refugees in Stuttgart, Germany. A total of 214 Syrian refugees participated in this study by filling a demographics questionnaire, the Acculturation Attitudes Scale (AAS-16), the Revised Sociocultural Adjustment Scale (R-SCAS), and the Mental Health Inventory (MHI-18). The results showed that the level of German language acquisition significantly correlated with sociocultural adjustment. No significant correlation was found between age and depression level and no significant difference in depression scores were found as a function of gender. Integration significantly correlated with sociocultural adjustment and mental health. Assimilation correlated significantly with sociocultural adjustment, and separation correlated negatively with mental health.