The study investigated the attitude of teachers towards the teaching of sexuality education in federal government colleges in Nigeria. In order to carry out the investigation, three hypotheses were formulated. An instrument known as "teachers' attitude towards teaching of sexuality education" (TATTOSE), was used to obtain information from the respondents. The instrument had a reliability coefficient of 0.79. It also had language appropriateness, content and facial validity. Four research assistants were used to administer 580 copies of the questionnaire to the respondents. Five hundred and twenty eight copies were retrieved showing 91.03 percent return rate. The data collected from the field were analyzed using t-test statistics. The research found out that there was no significant difference in the attitude of male and female teachers towards the teaching of sexuality education, that there was significant difference in the attitude of less experienced and experienced teachers towards the teaching of sexuality education. Finally, the study also revealed that there was no significant difference in the attitude of married and unmarried teachers towards teaching of sexuality education in Nigeria. One of the recommendations is that a curriculum of sexuality education should be drawn up for secondary schools.