Purpose: The purpose of this paper is to investigate the factors that influence Ghanaian tertiary students' career choices. The paper explores the dimensionality of the career choice factors within the Ghanaian context and also ascertains their degree of influence on students' career choices. Design/methodology/approach: The study employs survey method of research and a set of questionnaire was used to examine the factors that influence students' career choices. A total of 354 undergraduate students from the Ashesi University College in Ghana participated in the study. Factor analysis was conducted on the career choice factors and differences in response between science and business students were ascertained by means of independent sample "t"-test. Findings: The findings of this study indicate that university students in Ghana place much premium on intrinsic value and employability/financial prospect in their career choice decisions than such factors as prestige and desired working conditions. Research limitations/implications: The findings of this study are relevant for policymakers and tertiary education providers interested in making the study of science an attractive option for university students in Ghana. Originality/value: The findings of this paper highlight some of the underlining reasons for the unpopularity of the study of sciences among university students in Ghana.