Purpose: The purpose of this paper is to develop a conceptual framework along with a set of hypotheses that reflects the dynamic relationships that operate within an entrepreneurial land-based university in order to then undertake empirical research. Design/methodology/approach: This paper, through reflection on existing literature, critiques the interactions between student, academic, educational institution and industry in order to conceptualise the entrepreneurial modus operandi of a land-based university. Findings: Specialist universities, such as those that serve the land-based sector, need to demonstrate multiple excellences not only in terms of the education they provide for students, but also in terms of consistently meeting or exceeding government, research community, employers and societies expectations. An institutional framework must be in place to facilitate and enhance the quadruple interface of academic, institutional, industry and student entrepreneurial behaviour. The social and economic factors that mediate the dynamics within this framework first underpin student development supporting them to reach their potential, second inform teaching excellence and research practice and finally, lead to outcomes that contribute to the global, national and regional economy. Originality/value: This paper is of value for those working in the educational sector as the model outlined can be used to critically reflect on current principles and practice and derive options for action to embed entrepreneurship more deeply within the organisational culture of a university.