The aim of this study was to investigate the effects of physical activity with music on motor development and performance in children with developmental deficiencies. The study includes twenty children with developmental deficiencies, aged between 10-15 years old. Children were classified into two groups randomly and both groups were given 1 hour of training 3 days a week for 20 weeks. Physical activity with English and Spanish verbal song was used for the first group and only physical activity for the second group. Each participant participated in shuttle, shuttle run, flexibility, standing long jump, vertical jump tests. The fatigue parameter of children was evaluated using the Visual Analog Scale. As a result of this study, it has been shown that physical activity with music is more effective method to improve motor development and performance levels of children with developmental deficiencies.