According to the most recent data from the federal Chemical Safety and Hazard Investigation Board, between 2001 and 2011, more than 120 university laboratory accidents have caused injuries (including one death) and millions of dollars in damages. Laboratory-safety lessons normally comprise lecture slides alongside occasional movies and tours of laboratory facilities. This approach limits the realism of safety instruction within the laboratory. In addition, enthusiasm for laboratory-safety lectures is often low for both instructors and participants. To address these issues, we have developed an augmented-reality (AR) program to increase enthusiasm and enhance the learning experience for laboratory safety using Microsoft HoloLens. AR is an emerging field that uses computer technologies to generate realistic images, sounds, and other sensations that replicate a real environment. When compared with static or one-sided laboratory lectures, our approach creates an interactive learning environment where students must physically move around the laboratory to learn about laboratory safety. As each of the images and holograms for this open-source program can be placed in any location for any laboratory configuration, our program is designed to be used in any laboratory around the globe.