The paper suggests that today's world is a VUCA (volatile-uncertain-complex-ambiguous) world, based on the Fourth Industrial Revolution in which machine intelligence and technology are transforming almost every field of human endeavor--all against a backdrop of climate change, social and political turmoil, and enormous and growing wealth inequity. American higher education is not suited to a VUCA world. Its bias towards hierarchy, rigid department/disciplinary/territorial structures, and slow pace of change, with which comes more attention to process than to outcomes in many instances, do not lend themselves to agility and change. In a world where organizations need to agilely respond to threats and opportunities, higher education is structurally ill-suited for survival. Three major challenges must be confronted in the next ten years: (1) The need for a coherent learning eco-system in which learners move in and out over a lifetime with a far greater variety of providers and granularity of learning experiences; (2) Shifting from a largely one-size-fits-all model of industrial education to curated and customized learning finely tuned to what a learner needs at the time of engagement, robustly supported by technology; and (3) Rethinking education and curriculum for a world of human-machine hybrid work, in which whole job categories (and thus majors) are taken over by machines, others are performed in human-machine hybrids, and others remain human only. That rethinking of work will extend to the jobs that get done within educational providers, including colleges and universities. Four strategies to help institutions start to reposition themselves to survive and thrive are presented.