The purpose of this article is not to provide an exhaustive literature review of learning with mobile devices, but rather offer an overview of learning with mobile devices that provides context for this special issue and its manuscripts. Methodologically, we placed more emphases on experimental or quasiexperimental design when possible, as we felt that it was important to offer the readers data and evidence on learning with mobile devices. We provide a condensed overview of learning with mobile devices in K-12 and higher education, and offer summaries of the relevant research for ebooks, podcasts, audience response systems, and augmented reality, as related to mobile devices. Last, we suggest that technology is simply a medium or tool, and that future research should explore how mobile devices can support learning with evidence-based practices and Mayer's 13 principles of multimedia learning.