Media literacy may help medical trainees optimize evidence-based decision-making. Many prescriptions written are not evidence-based, resulting in unnecessary morbidity and mortality. In this study, we aimed to assess feasibility, acceptability, and initial efficacy of a media literacy prescribing program. We recruited 30 medical students, 70% of whom completed animated video modules about pharmaceutical marketing and prescribing and all assessment activities. We used process evaluation and open-ended items to assess feasibility and acceptability, and we used knowledge tests before and after the intervention to assess efficacy. The program was feasible to implement and well-accepted by participants. After the educational intervention, knowledge and attitude targets around evidence-based prescribing and drug marketing improved.