The present study used a regression discontinuity approach to test whether schema-based instruction (SBI) was effective for students identified with varying levels of mathematics difficulties (MD) who received Tier-1 instruction. The performance of these students was compared to similar students who received business-as-usual Tier-1 instruction. Results indicated SBI on average raised scores regardless of whether a student was categorized as having MD on outcome measures of mathematics problem solving, suggesting that SBI is effective for a wide range of proportional reasoning skills and general mathematical proficiency, which broadens the population of students who could benefit from SBI. Standardized slopes for the treatment effect also provide evidence of the effectiveness of SBI. Implications for practice and research are discussed.