Nature, as a creative ontology, and the ethico-political possibilities inherent within have been seemingly occluded in the field of science education. By Thinking with Nature (TwN), we return to the ontological dimensions of practice and research methodology in science education. Drawing on new material feminisms, educators are invited to follow the contours of minor concepts with/in Nature. Thinking with Gilles Deleuze and Karen Barad, our theoretical tinkering follows the contours of "minority within Nature," as opposed to the passive observation of brute matter, to illuminate concepts of possibility hidden in plain sight: holobionts and lightning. By following Nature's inherent queerness, becoming-minor, TwN provokes an enactment of ethico-political response-ability in research on science education. Above all else, this paper should be read, not as a prescription, but a provocation for TwN and following the contours of minor(ity) concepts.