The present study explored work-related stress and career experiences of Asian-American social workers and assessed if their demographic characteristics, beliefs and orientations (altruism, idealism, and self-compassion), and work-related stressors might impact their professional quality of life (secondary trauma, compassion satisfaction, and burnout) and job-related health problems. Two hundred and eight (208) Asian social workers and students participated in a comprehensive online survey by providing basic demographic and work-related information and completing a set of standardized scales to assess their career experiences and work-related stress, as well as their psychological and physical well-being. Bivariate analyses and stepwise multiple regression analyses were used to estimate models that best predicted their experiences of secondary trauma, compassion satisfaction, burnout, perceived stress, and job-related health problems. The findings showed that higher perceived stress was associated with higher secondary trauma, burnout, job-related health problems, and lower compassion satisfaction. Work-related problems/stressors emerged as a very strong predictor of burnout and job-related health problems. Higher self-compassion was related to higher compassion satisfaction and lower secondary trauma and burnout. Self-compassion was found to be a very strong predictor of perceived stress. Implications of the findings for professional education and career development for Asian-American social workers were discussed.