The aim of this study is to analyze the effect of agility exercises applied on female students who play handball in school teams on the change of direction (COD) speed and speed in terms of different exercise frequencies for 10 weeks. 75 female students have participated in the study. The first group has been applied agility exercises of 20 minutes during the handball work-out after the warm-up exercises for 5 times a week, the second group was applied these exercises for 3 times a week and the third group was applied these exercises for 2 times a week. Before and after the 10 week agility exercises, the athletes' age, sports age, height, weight, Zigzag test (COD speed) and 20m speed test measurements were taken. After the exercises, COD speed and 20m speed measurements displayed a significance level of difference in terms of the groups (p<0,05). In terms of the COD speed, the average of the 3rd group is significantly higher than the average of the 1st group. In terms of 20m speed, the average of the 1st group is significantly lower than the averages of the 2nd group and the 3rd group and there is no significant difference between the 2nd and 3rd groups. In terms of the COD speed, the decrease in the 1st group is significantly higher than the decrease in the 2nd group and the measurements of the 1st and 2nd groups are significantly higher than the decrease in the 3rd group (3>2>1). In terms of the 20m speed measurement, the decrease in the 1st group is significantly higher than the decrease in the other two groups and there is no significant difference between the decrease values of the 2nd and 3rd groups. As a result, frequency in the agility exercises of female children who play handball in this age group is important. Within the scope of yearly planning, giving place to agility exercises in a regular manner 5 times a week each for 20 minutes can be stated to affect speed, agility and COD speed performance which are more important in this sport.