African American communities have experienced negative effects from a history of medical abuse, lack of proper research procedures, and misinterpretations of study findings because of racism. These past injustices have led to a mistrust of research and researchers. This paper focuses on how some methodological challenges, in a study funded by a National Institutes of Health grant on two low-income African American communities in Kentucky, were mediated through the collaboration of a multi-racial/ethnic team of researchers engaged in cross-disciplinary research. The information for this paper is based on the reflections of key members of the research team. The reflections show that having researchers with different epistemologies resulted in a culturally aware and sensitive study in which emic and etic research approaches were adopted. The inclusion of race-based epistemologies and close community ties were found to be particularly useful in building trust and getting the support of the two communities. However, these outcomes were only possible because research team members provided each other latitude for intellectual freedom and leadership.