This article, based upon the closing plenary delivered to the recent conference of Professional Practice, Education and Learning, reflects upon the developments of the ProPEL network over the past seven years and its possibilities for future directions. To provide some context for these reflections, the article begins by outlining key challenges facing contemporary professions and their education. Against these, I consider themes and emphases that have characterised ProPEL initiatives and the papers presented to its conferences. Then, I compare these to the sorts of questions and issues that appear to be most urgently debated in other scholarly communities concerned with changing professional work and knowledge, particularly the dramatic transformations of professional roles through new digital technologies and artificial intelligence, transnational demands and new organisational forms. The article ends with questions for educators researching professional practice: where we need more focus, where perhaps we need less, and what may be productive ways forward.