The dynamics of knowledge in society have transformed the conditions of professional work and learning. Professional expertise has become increasingly specialised, and practitioners are challenged to keep up with rapid developments in their fields. At the same time, the complexity of professional work requires the integration of different forms of knowledge and knowing. Against this background, the knowledge settings in which learners engage and the practices and resources these offer are of vital importance. This article addresses professional education as embedded in profession-specific 'machineries of knowledge construction', that is, the set of practices and arrangements through which knowledge and ways of knowing in a profession are generated. It is argued that such machineries span settings in education and work. Examples from research in three professional programmes are used to discuss how students are introduced to epistemic practices and resources in selected knowledge settings. Analytical attention is given to the dynamic interplay between people, practices, knowledge resources and educational arrangements as well as to how connections to work and the epistemic machinery are made. Taking these linkages into account is important for our understanding of what learning entails in different areas of expertise and how this may change over time.