Objectives: To describe the development of a collaborative partnership to improve birth outcomes in Harris County, Texas. Methods: State and city-level maternal and infant health data were re-analyzed and presented to stakeholders at the zip-code level to generate a renewed response to health issues in these populations, particularly infant mortality. Public and private sector stakeholders convened to form the Impacting Maternal and Prenatal Care Together (IMPACT) Collaborative, identifying four priority areas that required collaborative action. Results: Priority area action groups are currently working on strategies to improve maternal and infant health outcomes. Collaborative strategies include: raising patient and provider awareness, campaign partnerships, advocating for legislative change, and implementing community based programs. As a collaborative, IMPACT received funding to implement an evidence-based health education intervention for women at risk of having poor birth outcomes. Conclusions: Through the leveraging of resources, expertise, and leadership, collaborative partnerships are capable of formulating innovative ideas, developing sustainable solutions, and generating change at multiple levels.