Background: People with profound intellectual disability experience a high prevalence of visual disability, making them more dependent on sound. However, research addressing the influence of the auditory environment is scarce. Method: Observations of the auditory environments (soundscapes) and moods of people with profound intellectual and visual disabilities, in terms of core affect, were conducted in residential facilities by direct support personnel. Appraisals of soundscape and core affect dimensions were combined and analysed by means of multilevel linear regression. Results: Findings endorse a positive relationship between the observed pleasantness and eventfulness of soundscapes and core affect of people with profound intellectual and visual disabilities. Conclusion: Based on the results of this study we suggest a relationship between soundscapes and moods of people with profound intellectual and visual disabilities, as judged by staff members engaged in their environments. These findings give reason to believe that improved soundscapes could ameliorate the moods of the residents.