Interest in interdisciplinary programs in science, technology, engineering, and mathematics (STEM)-related fields at the graduate-degree level is widespread across American higher education. Using longitudinal qualitative interviews, this article considers the early career experiences of scholars who hold an interdisciplinary PhD in neuroscience. The scholars were interviewed first as doctoral students and then 6 years later. The findings illustrate the challenges of marketability, professional development, and balancing personal and career demands for interdisciplinary PhD recipients in STEM-related fields.