To remain competitive in an increasingly interdisciplinary world, graduate education must produce professionals who can understand both their scientific disciplines and the business environment in which they work. With the addition of applied learning components outside of the traditional scientific laboratory and training in business skills, Professional Science Master's programs (PSMs) help higher education adapt to this changing environment. The current study illustrates some models of PSMs and contains information on how institutions interested in using PSMs as a way to enhance applied learning at the graduate level can get started.