The present qualitative research study was designed to identify barriers to entrepreneurship development in Iran's higher education system. The present study is applied and developmental in terms of its objective and it is descriptive case study in terms of its nature and data collection. The study population includes 45 elites, scholars, policy-makers, planners, managers, specialists, and experts endowed with expertise and experience in the subject matter of this study in Yazd province, Iran, who are selected through purposive sampling method. To collect the required data, in-depth and semi-structured interviews are performed that are continued until the achievement of theoretical saturation. Following the implementation of open and refined coding processes, findings are illustrated in a four-dimensional model. The research model is represents the upcoming context of entrepreneurship development in Iran's higher education system. Finally, causal conditions leading to such impacts, consequences, and action strategies are proposed to reduce and alleviate the given impacts.