When a theoretical framework (and its components) is not clearly linked to research methods, researchers risk designing flawed studies, wherein the stated research question is inconsistent with the research design. Explicitly identifying one's theoretical orientation can provide an orderly schematic for linking observations from separate investigations (i.e. qualitative, quantitative) thereby facilitating understandings and guiding research designs particularly in fields of social and health sciences where complex phenomena are an aspect of the subject of inquiry. Although this has been established, "how" researchers might position their research theoretically to guide mixed methods research is less clear. In this paper, we propose the Before Design Theoretical Placement as a general guide for specifying and locating studies in a broader theoretical grounding, and discuss how it may inform overall study considerations. We then use this approach to illustrate how theories and methods can work together to facilitate professional knowledge development from a relational perspective.