Scientific inquiry activities are considered as productive science instruction to improve students' science learning and achievement. Supportive teacher-student relationships and positive disciplinary climate in the classroom are also two important factors that could facilitate student learning. This study investigates whether the association between the inquiry-based science activities and student science achievement varies by teacher support and disciplinary climate in science classrooms, particularly when taking into consideration of student gender difference and socioeconomic status (SES). This study performed regression analyses using Beijing, Shanghai, Jiangsu, and Guangdong (B-S-J-G-China) students' science performance and background survey data of 2015 Program for International Student Assessment (PISA). Results showed that disciplinary climate, rather than teacher support, could moderate the association between inquiry-based science activities and student science achievement for both genders. Implications for instruction and further research were discussed as well.