This study contributes on instructional methods from a validation technical point of view. The focus is on the evaluation of instructional methods in relation to knowledge processes in the act of learning. In questionnaires, computer science teachers, mathematics teachers, and English teachers evaluated 20 instructional methods in terms of knowledge processes (build, process, apply, transfer, evaluate, and integrate). The findings show that computer science teachers and mathematics teachers differ compared to English teachers on the assessment of instructional methods with respect to knowledge processes. The findings represent an important contribution for theory construction concerning the learning effectiveness of instructional methods.